Rat Anti-Mouse Siglec-E Antibody (S-3881)
SKU: 59052952520

Rat Anti-Mouse Siglec-E Antibody (S-3881)

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Description

Rat Anti-Mouse Siglec-E Antibody (S-3881)Product Specification Host Rat Antigen Siglec E Synonyms Sialic acid binding Ig like lectin E; Siglece; Siglecl1 Location Membrane Accession Q91Y57 Clone Number S 3881 Antibody Type Rat mAb Isotype IgG2b Application FCM Reactivity Ms Positive Sample BALB c mouse splenocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt

Product Specification


Host Rat
Antigen Siglec-E
Synonyms Sialic acid binding Ig-like lectin E; Siglece; Siglecl1
Location Membrane
Accession Q91Y57
Clone Number S-3881
Antibody Type Rat mAb
Isotype IgG2b
Application FCM
Reactivity Ms
Positive Sample BALB/c mouse splenocytes
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:200 Ms

Background

Siglec-E, the murine orthologue of human Siglec-9, is a sialic acid-binding immunoglobulin-like lectin expressed predominantly on myeloid cells (macrophages, neutrophils, dendritic cells) that functions as a critical immunosuppressive checkpoint by recruiting SHP-1/2 phosphatases upon engagement of sialoglycan ligands, thereby attenuating TLR4- and TRIF-dependent signaling, dampening NF-κB activation and pro-inflammatory cytokine production, and exerting neuroprotective and anti-atherogenic effects through inhibition of microglial activation and CD36-mediated oxidized LDL uptake.

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SKU: 59052952520

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4.1 ★★★★★
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Amy
Natrona Heights, US
★★★★★ 5
Great Resource Even for Non-Professionals
Format: Paperback
I am not a psychotherapist, but I ordered the workbook to learn more about somatics. It’s a very good resource from what I’ve experienced so far. I love how the concepts are plainly explained in (mostly) everyday language. I’m a helper and healer by nature, and I think I will get a lot of mileage out of the well-presented activities in the book. If you’re not a professional but are looking for ways to expand your knowledge of healing, trauma response, and the human body, you’ll like the practical nature of this one.
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Reviewed in the United States on April 21, 2025
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alex
Port Orchard, US
★★★★★ 5
What a FANTASTIC resource (WITH PDF FILES!!!)
Format: Paperback
I normally do not write reviews on Amazon, but thought I would do so in this case. I bought the book a few months ago and have really begun to digest the amazing quality of work that has been put into this. Prior to purchase I almost did not buy since someone else noted in their review that there are no PDFs. I reached out to the author, and she was very responsive and warm to my concern and advised there is a link within the book to download the PDFs. Sure enough, the book arrived and I was able to download the digital files! I have used to book and its tools to create two therapy groups that are heavily influenced by the content. After running both groups three times, I nothing but good things to say about this resource. My clients, who initially were resistant to somatic work, have all come around to love this group. In fact, they are two of the more popular groups at my program! Individuals who have been so traumatized that their usual report of "I feel nothing" has shifted. One client has been able to turn her whole narrative of her body being the enemy (for betraying her per trauma) to "my body empowers me. Even when I don't like what it is telling me, it is protecting me and moving me through life." I am so grateful for this book and the different perspective that it provided me in my practice.
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Reviewed in the United States on December 19, 2019
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Michelle W
Lowell, US
★★★★★ 5
AMAZED
Format: Paperback
This book is an incredible tool to add to the way I practice. I intuitively already used a lot of skills in this book and never realized what I was doing. I've always had this innate understanding that the body plays such an important role in healing. No wonder people gain a ton of weight after sexual trauma, or why we feel so good after exercise, yoga, dance etc. I was trained in a somatic and attachment focused protocol for EMDR and have been so intrigued to learn more about somatic exercises to incorporate with my clients. I'm so excited to start using this material! This has been on my wishlist for a long time, go ahead and buy it! You won't regret it.
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Reviewed in the United States on March 6, 2020
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W.T. Windham
Waukegan, US
★★★★★ 5
A dog that fulfilled his dream.
Format: Hardcover
It’s a cute story. If you are a dog lover and honor service dogs, you’ll love the book.
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Reviewed in the United States on April 14, 2026
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A. Nigel
Phoenix, US
★★★★★ 5
Adorable book, sweet illustrations, a great introduction to service dogs
Format: Hardcover
Wonderful tale (no pun intended) about service dogs and in particular highlighting Canine Companions. Canine Companions for Independence is an incredible non profit that has been providing service dogs for many years. If you are looking for a sweet book for anyone this is it. We plan on giving it to many people this holiday season. And if you are looking for a good non profit to donate to this is one to consider. Visit their website and check them out!
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Reviewed in the United States on October 28, 2025

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