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Description
Huntingtin Recombinant Rabbit mAb (S-1481-147)Product Specification Host Rabbit Antigen Huntingtin Synonyms Huntington disease protein (HD protein); HD; IT15; HTT Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P42858 Clone Number S 1481 147 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt Positive Sample HeLa, SH SY5Y, Neuro 2a, mouse brain, PC 12, rat brain Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | Huntingtin |
| Synonyms | Huntington disease protein (HD protein); HD; IT15; HTT |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P42858 |
| Clone Number | S-1481-147 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, SH-SY5Y, Neuro-2a, mouse brain, PC-12, rat brain |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| ICC | 1:2000 | Hu |
Background
Huntingtin (HTT) is a large soluble protein composed of approximately 3144 amino acids, with a molecular weight of around 348 kDa. It is highly expressed in the central nervous system, particularly in neurons of the cerebral cortex and hippocampus. Huntingtin plays crucial roles in various cellular processes, including clathrin-mediated endocytosis, axonal transport, and synaptic signal transduction. It also helps protect neurons from apoptosis.
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