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Description
AXL Recombinant Rabbit mAb (S-2199-80)Product Specification Host Rabbit Antigen AXL Synonyms Tyrosine protein kinase receptor UFO; AXL oncogene; UFO Immunogen Recombinant Protein Location Cell membrane Accession P30530 Clone Number S 2199 80 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample HeLa, HUVEC, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol,
Product Specification
| Host | Rabbit |
| Antigen | AXL |
| Synonyms | Tyrosine-protein kinase receptor UFO; AXL oncogene; UFO |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P30530 |
| Clone Number | S-2199-80 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | HeLa, HUVEC, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Mk |
| IHC-P | 1:100 | Hu |
| ICC | 1:500 | Hu |
Background
AXL protein is a receptor tyrosine kinase and a member of the Tyro3-Axl-Mer (TAM) subfamily, characterized by an extracellular domain with two immunoglobulin-like motifs and two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein Gas6. This binding induces AXL dimerization and autophosphorylation, activating downstream molecules like PI3-kinase subunits, GRB2, and PLCG1, which in turn triggers AKT kinase activation. AXL is involved in various cellular functions, including cell survival, proliferation, migration, and differentiation. It also plays a role in immune modulation by inhibiting Toll-like receptor-mediated innate immune responses. Additionally, AXL serves as a host cell receptor for several viruses, such as Marburg, Ebola, Lassa, and potentially SARS-CoV-2.
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